Evaluation of Serum Hormones and Biochemical Tumor Markers among Breast Cancer Patients in the South-South Region, Nigeria

Breast cancer remains one of the most frequent malignancies in women and primary cause cancer-related death all over world. Hormones tumor biomarkers have been implicated as possible causes prognostic breast cancer. The present study investigated use serum hormonal levels biomarkers; Carcinoembrvonic antigen (CEA), (CA 15-3) for diagnosis Cancer, generation different subtypes using Estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2). This is a cross-sectional comprising 120 subjects; sixty patients, apparently healthy who served control. One hundred twenty blood samples were collected analyzed estrogen, progesterone, antigen, antigen. results showed that peak age incidence was 40-49 years. Majority (56.7%) cases menopausal women, while 43.3% their premenopausal period. Serum concentrations elevated significantly (p<0.05) patients than control group. Premenopausal higher estradiol, those during postmenopausal HER2 negative subtype (50.0%) prevalent 8.4% triple (ER–/PR–/HER2–) cases, 1.7% positive (ER+/PR+/HER2+) cases. strongly associated with changes especially estrogen periods women. Thus, determination concentration statuses could help prognosis